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Lacrimal gland involvement can lead to aqueous tear deficiency resulting in severe keratoconjunctivitis sicca (KCS) which can significantly increase the morbidity of patients with chronic GVHD.

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This disorder can result from witnessing or experiencing an event involving serious injury, or threatened (or experiencing the death or threatened death of another.

Cyclosporine is used to prevent organ rejection after a kidney, liver, or heart transplant.

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The trials of Cyclosporine used low doses compared to the UC trials and only oral forms.

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